n brand names, is relatively inexpensive. Previous research has focused on whether metformin might reduce the risk of getting prostate cancer, but most studies were negative. Some experts believe the drug instead works to improve survival once the cancer occurs. In the new study, published online Aug. Nike Air Max Zero X 5 in the Journal of Clinical Oncology, Margel looked at more than 3,800 diabetic men aged 67 or older Nike Air Max Zero Perth
The findings point to a need for a large study in which men with early stage prostate cancer are assigned to a metformin group or placebo g.
risk from prostate cancer death for every additional six months of use after their cancer diagnosis. The Nike Air Max Zero Persian
The men took the metformin for a median of 19 months (half longer than that, half shorter) before the cancer was diagnosed and nearly nine months after. During roughly four years of follow up, Margel found those who took metformin had a 24 percent reduction in Nike Air Max Zero Blue And White
risk reduction of death from other causes was initially the same but declined over time. In both instances, although an association was found between metformin and survival, a direct cause and effect relationship was not established. Although other diabetes drugs work by increasing the body's insulin production, metformin is an "insulin sensitizer" that works by making the body more sensitive to the insulin already produced. Insulin is needed to move glucose into cells for energy.
who lived in Ontario. About one third were taking metformin at the study's start. Others were using different diabetes drugs.
Some research suggests that high insulin levels can influence cancer growth. Metformin, by not increasing the body's insulin production, may decrease cancer cells' growth, some experts say. Typical side effects of the drug are mild diarrhea and stomach problems, Margel said. "Usually they subside after one or two weeks," he said. In their next study, the researchers plan to test metformin in patients with prostate cancer but not diabetes. "Metformin is very safe to use among nondiabetic patients," Margel said.
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